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Hypophyseal tumor and gynecomastia preceding bilateral breast cancer development in a man
Author(s) -
Olsson Hakan,
Alm Per,
Kristoffersson Ulf,
LandinOlsson Mona
Publication year - 1984
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19840501)53:9<1974::aid-cncr2820530928>3.0.co;2-g
Subject(s) - gynecomastia , medicine , breast cancer , male breast cancer , prolactin , cancer , hormone , endocrinology , testosterone (patch) , estrogen , oncology
The case is reported of a 48‐year‐old man who, 26 years after treatment for a hypophyseal tumor and 11 years after the onset of bilateral gynecomastia, developed cancer of the left breast. Ten years after the first breast cancer operation a new cancer developed in his right breast. Hormonal investigation at the time of the second breast cancer operation revealed a low S‐FSH and a relative estrogen excess compared to testosterone. Values of thyroid and adrenal hormones were essentially normal, while P‐prolactin was elevated. Stimulatory tests of the hypophyseal function were in accordance with a partial hypophyseal insufficiency affecting the hypophyseal‐gonadal axis. Also, a weak elevation of S‐HGH was noted by an insulin tolerance test. Immunohistochemical analysis of the pituitary tumor 36 years later showed that the tumor could be classified as a prolactinoma. Cytogenetic analysis revealed a normal male chromosome karyotype.