Premium
Ewing's sarcoma in female siblings: A clinical report and review of the literature
Author(s) -
Joyce Michael J.,
Harmon David C.,
Mankin Henry J.,
Suit Herman D.,
Schiller Alan L.,
Truman John T.
Publication year - 1984
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19840501)53:9<1959::aid-cncr2820530926>3.0.co;2-9
Subject(s) - ewing's sarcoma , sarcoma , medicine , genotyping , chromosomal abnormality , chromosomal analysis , prophase , genetics , immunology , pathology , karyotype , genotype , biology , chromosome , gene , meiosis
The third reported case of Ewing's sarcoma in siblings is presented. All reported siblings to date have been female. Because of the most unusual occurrence, clues for environmental and genetic factors in the origin of the tumors were sought. Human leukocyte antigen (HL‐A) genotyping, routine chromosomal, and prophase chromosomal studies were obtained. Despite extensive study, the existence of an infectious agent, exposure to a carcinogen, or genetic abnormality could not be defined.