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Nuclear DNA content in dimethylhydrazine‐induced colonic carcinoma and mucosal dysplasia in rats
Author(s) -
Kimura Osamu,
Kaibara Nobuaki,
Miyano Yosuke,
Okamoto Tsuneyuki,
Tamura Hideaki,
Yurugi Eiichi,
Koga Shigemasa
Publication year - 1984
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19840501)53:9<1918::aid-cncr2820530918>3.0.co;2-b
Subject(s) - dysplasia , carcinoma , 1,2 dimethylhydrazine , dna , medicine , pathology , nuclear dna , gastroenterology , distribution (mathematics) , colonic carcinoma , dimethylhydrazine , colorectal cancer , cancer , biology , biochemistry , gene , mitochondrial dna , mathematical analysis , mathematics
Mucosal dysplasia and carcinoma infiltrating the submucosal layer were induced in rats with dimethylhydrazine. The nuclear DNA content of the cells was measured, and the correlation between the DNA distribution pattern and histopathologic findings was evaluated. In mild and moderate dysplasias, histograms of the nuclear DNA content showed a narrow range of distribution with a sharp peak in the diploid area. In severe dysplasia, however, there was wide distribution and no peak value; this was reminiscent of carcinoma. Based on the findings of this report, the authors suggest that severe dysplasia be regarded as intramucosal carcinoma.