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Massive IgE‐hyperimmunoglobulinemia and storage histiocytosis in Sézary syndrome: A postmortem study
Author(s) -
Miyayama Haruhiko,
Takemiya Masataka,
Takahashi Kiyoshi,
Sakazaki Yoshikado,
Sato Masahiko,
Mitsuya Hiroaki
Publication year - 1984
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19840501)53:9<1869::aid-cncr2820530913>3.0.co;2-l
Subject(s) - immunoglobulin e , medicine , malignant histiocytosis , autopsy , lymphoma , pathology , histiocyte , immunology , antibody , generalized lymphadenopathy , bone marrow , lymph , t cell , immune system
Substantial evidence has accumulated that the Sézary syndrome is grouped together as “cutaneous T‐cell lymphoma” and forms a subset of T‐cells programmed for helper interactions with B‐cells in their production of immunoglobulins; IgA, IgG, and IgM. The authors describe an autopsy case of a 64‐year‐old Japanese man, with cutaneous T‐cell lymphoma in association with IgE‐type lambda hyperimmunoglobulinemia. The serologic and immunocytochemical studies suggest that Sézary cells from our patient are T‐cell proliferations in association with IgE‐specific helper activity. In addition, histiocytosis was interestingly noted, for the first time, in the generalized lymph nodes, spleen, and bone marrow by the autopsy. The cytoplasm of swelled histiocytes contained IgE‐type lambda immunoglobulin by the PAP method that probably represented altered immunoglobulin.