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Hodgkin's disease with leptomeningeal involvement: Report of a case with long survival
Author(s) -
Orlowski Edward P.,
Hansen Richard M.,
Anderson Tom,
Hanson Gerald A.,
Kun Larry E.,
Pisciotta Anthony V.
Publication year - 1984
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19840501)53:9<1833::aid-cncr2820530905>3.0.co;2-0
Subject(s) - procarbazine , medicine , dacarbazine , abvd , vincristine , vinblastine , prednisone , bleomycin , methotrexate , lomustine , nitrogen mustard , surgery , ommaya reservoir , chemotherapy , cyclophosphamide
A 30‐year‐old white man with Stage IV B Hodgkin's disease, mixed cellularity type, developed leptomeningeal involvement shortly after relapsing on nitrogen mustard, Oncovin (vincristine), procarbazine, and prednisone (MOPP), and while receiving Adriamycin (doxorubicin), bleomycin, Velban (vinblastine), and dacarbazine (ABVD). Whole brain irradiation and intrathecal methotrexate were successfully incorporated into his treatment program. The patient has now been in complete remission for more than 40 months. A review of this rare complication of Hodgkin's disease is presented.