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Localization of free secretory component in pleomorphic adenomas of minor salivary gland origin
Author(s) -
Fantasia John E.,
Lally Edward T.
Publication year - 1984
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19840415)53:8<1786::aid-cncr2820530830>3.0.co;2-w
Subject(s) - myoepithelial cell , secretory component , histogenesis , salivary gland , pathology , glycoprotein , duct (anatomy) , epithelium , biology , secretory protein , antiserum , mucin , immunohistochemistry , antibody , secretion , medicine , endocrinology , immunology , microbiology and biotechnology
Secretory component (a glycoprotein) is an antigenically distinct portion of the secretory immunoglobulin A, which has been identified in a number of normal and neoplastic epithelial cells. Localization of secretory component was determined in pleomorphic adenomas of minor salivary gland origin using the four‐step peroxidase–antiperoxidase technique. Antiserum that detected only free secretory component (FSC) was used. Staining for secretory component was noted in the epithelium that lined duct‐like spaces; but was absent in myoepithelial cells and mucous acini. These findings suggest a role for FSC in evaluating the histogenesis of various salivary gland neoplasms.