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Small cell undifferentiated carcinoma of the esophagus: Case report with hormonal studies
Author(s) -
Johnson Frank E.,
Clawson Mark C.,
Bashiti Hind M.,
Silverberg Alan B.,
Broun Goronwy O.
Publication year - 1984
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19840415)53:8<1746::aid-cncr2820530822>3.0.co;2-v
Subject(s) - medicine , esophagus , immunoperoxidase , hormone , pathology , carcinoma , chemotherapy , stain , radiation therapy , staining , antibody , immunology , monoclonal antibody
This report details clinical and pathologic aspects of a case of small cell undifferentiated carcinoma of the esophagus. Transmission electron microscopic examination demonstrated neurosecretory granules, and indirect immunoperoxidase stain for adrenocorticotropic hormone (ACTH) was positive. However, the authors detected no abnormal hormone levels in urine or blood. The calculated tumor doubling time was approximately 2 days. The fulminant nature of this carcinoma was also evident from the rapid clinical progression in spite of surgical excision, radiotherapy, and chemotherapy.