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Prevalence of delta antigen/antibody in B‐viral‐associated hepatocellular carcinoma
Author(s) -
Govindarajan Sugantha,
Hevia Francisco J.,
Peters Robert L.
Publication year - 1984
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19840415)53:8<1692::aid-cncr2820530812>3.0.co;2-5
Subject(s) - medicine , hepatocellular carcinoma , antibody , antigen , delta , hepatitis b antigens , carcinoma , virology , immunology , hepatitis b virus , virus , engineering , aerospace engineering
Sera from 39 patients with B‐viral associated hepatocellular carcinoma were studied for the presence of delta antibody using solid‐phase blocking radioimmunoassay. Only one patient (2.5%) had circulating delta antibody in the serum, and stainable delta antigen in the nuclei of the nontumor liver. A similar study of the sera of 57 patients with chronic B‐viral disease without hepatocellular carcinoma revealed 18 patients (31.5%) with delta antibody. This significant difference ( P > 0.001) in the prevalence of delta antibody among these two groups is probably related to the epidemiologic background, reflected as a racial difference.