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Tumor‐associated fever in breast cancer
Author(s) -
Chawla Sant P.,
Buzdar Aman U.,
Hortobagyi Gabriel N.,
Blumenschein George R.
Publication year - 1984
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19840401)53:7<1596::aid-cncr2820530729>3.0.co;2-s
Subject(s) - medicine , breast cancer , chemotherapy , cancer , disease , bone marrow , metastasis , fever of unknown origin , oncology , surgery
Seventeen breast cancer patients with tumor‐associated fever are described. All other potential causes of fever were excluded in each patient, and it was diagnosis of exclusion. Fever was the first manifestation of recurrence in seven patients. In ten patients fever developed in association with new sites of metastases or progression of disease. New sites of metastasis in most of the patients were liver, bone marrow, or lungs. Seven patients had metastatic disease that responded to chemotherapy or hormonal therapy; fever subsided in only these patients (responding group). In nine patients neither tumor nor fever showed response to systemic treatment (nonresponding group). Overall survival after onset of fever was better in the responding group than nonresponding group.