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Helper T‐cell lymphoma with marked plasmacytosis and polyclonal hypergammaglobulinemia a case report
Author(s) -
Tamaki Toshiharu,
Katagiri Shuichi,
Kanayama Yoshio,
Konishi Ichiro,
Yonezawa Takeshi,
Tarui Seiichiro,
Kitani Teruo
Publication year - 1984
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19840401)53:7<1590::aid-cncr2820530728>3.0.co;2-c
Subject(s) - plasmacytosis , medicine , hypergammaglobulinemia , polyclonal antibodies , lymphoma , pathology , immunology , antibody , multiple myeloma
Abstract A case of malignant lymphoma with a helper activity of neoplastic cells is reported. On admission, a significant number of plasma cells of polyclonal nature were seen in the peripheral blood, and polyclonal hypergammaglobulinemia was seen. The biopsied lymph node showed poorly differentiated lymphocytic lymphoma with marked proliferation of plasma cells. At the terminal stage, the patient became leukemic in contrast with the disappearance of plasma cells from the peripheral blood. Although the leukemic cells failed to form sheep erythrocyte rosettes, they were considered to be of T‐cell origin morphologically. Cytochemically, they had a “dot”‐like pattern of α‐naphtyl acetate esterase and acid phosphatase activity. Ultrastructurally, they had highly convoluted nuclei, and cytoplasmic clustered dense bodies. They showed marked helper activity on pokeweed mitogen‐induced B‐cell differentiation in vitro. This case may provide a novel view concerning the cause of hypergammaglobulinemia induced by lymphoproliferative disorders.