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Production of immunoreactive‐polypeptide hormones in cervical carcinoma
Author(s) -
Inoue Takeo,
Yamaguchi Ken,
Suzuki Harumi,
Abe Kaoru,
Chihara Tsutomu
Publication year - 1984
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19840401)53:7<1509::aid-cncr2820530715>3.0.co;2-4
Subject(s) - somatostatin , radioimmunoassay , endocrinology , pancreatic polypeptide , hormone , vasoactive intestinal peptide , calcitonin , medicine , adrenocorticotropic hormone , peptide hormone , glucagon , melanocyte stimulating hormone , neuropeptide , receptor
The levels of immunoreactive‐polypeptide hormones were measured in tissue extracts of eight uterine cervical cancers by specific radioimmunoassays. In one case with argyrophil granules, high levels of somaostatin, pancreatic polypeptide, calcitonin, and vasoactive intestinal polypeptide (VIP) were found, ranging from 160 to 880 ng/g tissue. A second argyrophil cancer contained 310 ng/g tissue of somatostatin, and a third contained 1100 ng/g tissue of adrenocorticotropic hormone (ACTH) and 380 ng/g of β‐melanocyte‐stimulating hormone (β‐MSH). In addition, of the five nonargyrophil cancers tested, four contained calcitonin, three had VIP, two had either somatostatin or glucagon, and one contained ACTH and β‐MSH; the measured levels of these hormones ranged from 1.4 to 23 ng/g tissue. Gel filtration on a Sephadex G‐75 column showed that the immunoreactive‐polypeptide hormones in the first case were chromatographically similar to the authentic or prehormones. These results indicate that ectopic production of multiple immunoreactive‐polypeptide hormones is common not only in argyrophil cell carcinoma, but also in nonargyrophil cell carcinoma of the cervix.