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Retroperitoneal lymphadenectomy and aggressive chemotherapy in nonbulky clinical stage II nonseminomatous germinal testis tumors
Author(s) -
Pizzocaro Giorgio,
Zai Fulvio,
Milani Angelo,
Piva Luigi,
Salvioni Roberto,
Pasi Massimo,
Pilotti Silvana,
Monfardini Silvio
Publication year - 1984
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19840315)53:6<1363::aid-cncr2820530624>3.0.co;2-i
Subject(s) - medicine , stage (stratigraphy) , vinblastine , lymphadenectomy , chemotherapy , bleomycin , surgery , testicular cancer , primary tumor , metastasis , cancer , paleontology , biology
In a former series of 60 resected Stage II nonseminomatous germinal testis tumors the authors succeeded in demonstrating that adjuvant cisplatin, vinblastine, and bleomycin (PVB) was able to significantly improve survival (100% in 11 treated versus 28.5% in 7 historical controls, P < 0.01) only in patients with retroperitoneal metastases > 5 cm, macroscopic extranodal spread, tumor invasion into retroperitoneal veins (pathologic Stage II‐C). Forty‐eight evaluable patients with clinical nonbulky Stage II nonseminomatous testis cancer underwent retroperitoneal lymphadenectomy as primary treatment. Four courses of postoperative PVB were administered only to 18 clinically understaged patients (14 pathologic Stage II‐C, and 4 postoperatively reclassified as Stage III). The remaining 30 patients were followed at monthly intervals. After a median follow‐up of 25 months, relapses were: 1 (10%) in 10 pathologic Stage I patients; 8 (40%) in 20 pathologic Stage II‐A and II‐B; null in the 18 treated. Eight of the nine patients (89%) who had relapse entered continuous complete remission following salvage therapy. The overall 2‐year disease‐free survival in this case series is 98%. Retroperitoneal lymphadenectomy followed by compulsive follow‐up and selective use of aggressive chemotherapy is an alternative to remission induction chemotherapy as primary treatment in clinical nonbulky Stage II nonseminomatous testis cancer, and to immediate adjuvant chemotherapy in all patients with resected Stage II disease. Cancer 53:1363‐1368, 1984.