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A prospective postoperative evaluation of urinary tumor‐associated antigens in sarcoma patients. Correlation with disease recurrence
Author(s) -
Huth James F.,
Gupta Rishab K.,
Eilber Frederick R.,
Morton Donald L.
Publication year - 1984
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19840315)53:6<1306::aid-cncr2820530614>3.0.co;2-g
Subject(s) - medicine , urine , urinary system , sarcoma , disease , complement fixation test , prospective cohort study , antigen , cancer , gastroenterology , surgery , urology , pathology , immunology , antibody , serology
Tumor‐associated antigens (TAA) excreted into the urine of sarcoma patients can be detected by the complement‐fixation assay. The authors prospectively measured TAA levels in the urine of 50 sarcoma patients postoperatively to determine whether reappearance of antigen in the urine would be predictive of disease recurrence. Twenty‐five patients developed recurrence of their disease in the postoperative period, and 24 (96%) had reappearance of antigen in the urine 10.1 ± 9.2 months prior to clinical evidence of recurrence. Of the 25 patients who remained disease free (mean follow‐up, 48 months), 23 of 25 (92%) were urinary‐antigen negative at last follow‐up, although 8 patients had transient elevations of urinary TAA early in the postoperative period. Results indicate that postoperative measurement of urinary TAA in sarcoma patients permits selection of a subset of individuals at high risk for the development of recurrence. This knowledge can be of assistance in the postoperative management of these patients. Cancer 53:1306‐1310, 1984.