Premium
Seminoma in a 46, XX true hermaphrodite with positive H‐Y antigen. A case report
Author(s) -
Nichter Larry S.
Publication year - 1984
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19840301)53:5<1181::aid-cncr2820530525>3.0.co;2-5
Subject(s) - seminoma , hermaphrodite , serology , antigen , medicine , cancer , phenotype , gene , pathology , immunology , biology , antibody , genetics , chemotherapy , ecology
This case study represents the first report of a 46, XX phenotypic male true hermaphrodite with a pure seminoma. Serologic testing of tissue demonstrated the presence of the H‐Y antigen. This finding supports the theory that the H‐Y gene is essential for primary sex determination and raises the possibility that it may also be the specific factor responsible for malignant degeneration of dysgenetic gonads. Cancer 53:1181‐1184, 1984.