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Plasma carcinoembryonic antigen and acinar cell carcinoma of the pancreas
Author(s) -
Horie Yutaka,
Gomyoda Manabu,
Kishimoto Yukihiro,
Ueki Juichi,
Ikeda Fumiaki,
Murawaki Yoshikazu,
Kawamura Manabu,
Hirayama Chisato
Publication year - 1984
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19840301)53:5<1137::aid-cncr2820530520>3.0.co;2-7
Subject(s) - carcinoembryonic antigen , medicine , pancreas , pathology , carcinoma , ductal cells , pancreatic cancer , cancer , adenocarcinoma , acinar cell
Seventeen patients with histologically proven pancreatic cancers were studied in order to clarify the relationship of histologic types to plasma carcinoembryonic antigen (CEA) values. Two cases with marked elevation of plasma CEA values having 6100 ng/ml and 2500 ng/ml, respectively, disclosed histologically acinar cell carcinoma and mixed acinar and ductal cell carcinoma, respectively. Despite of massive hepatic metastases, the other 15 cases with ductal cell carcinoma, including 3 cases with cystadenocarcinoma, adenoacanthoma, and undifferentiated pancreatic cancer, respectively, showed normal or very modest elevation of plasma CEA values. No correlation was obtained between plasma CEA values and several biochemical tests. Two patients with marked elevation of plasma CEA value revealed strong staining in the cancerous areas of the pancreas by using a peroxidase‐antiperoxidase staining technique. These findings suggest that acinar cell carcinoma of the pancreas may contribute to increase the circulating plasma CEA value. Cancer 53:1137‐1142, 1984.