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Experimental models for gastric leiomyosarcoma. The effects of N‐Methyl‐N′‐Nitro‐N‐Nitrosoguanidine in combination with stress, aspirin, or sodium taurocholate
Author(s) -
Cohen Albert,
Geller Stephen A.,
Horowitz Isadore,
Toth Lewis S.,
Lawrence Werther J.
Publication year - 1984
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19840301)53:5<1088::aid-cncr2820530512>3.0.co;2-y
Subject(s) - aspirin , methylnitronitrosoguanidine , medicine , carcinogen , adenocarcinoma , stomach , sodium , cancer , pharmacology , biochemistry , chemistry , mutation , organic chemistry , gene
A series of experiments was devised to determine possible modifying effects of stress, aspirin, and sodium taurocholate on the activity of N‐methyl‐N′‐nitro‐N‐nitrosoguanidine (MNNG) in the Buffalo rat stomach. MNNG is a well known, direct‐reacting carcinogen, and has been a reliable agent for the experimental production of gastric adenocarcinoma. The authors were able to produce adenocarcinomas in rats, but found a great number of gastric leiomyosarcomas. These occurred only in the groups given MNNG in combination with stress, aspirin, or sodium taurocholate, and did not occur in experimental groups given either MNNG, stress, aspirin, or sodium taurocholate alone, and did not occur in the control group. Cancer 53:1088‐1092, 1984.