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A morphologic and histochemical study of metaplastic polyps of the colorectum
Author(s) -
Jass Jeremy R.,
Filipe M. Isabel,
Abbas Soufyan,
Falcon Charles A. J.,
Wilson Yannoulla,
Lovell David
Publication year - 1984
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19840201)53:3<510::aid-cncr2820530324>3.0.co;2-o
Subject(s) - medicine , dysplasia , pathology , malignant transformation , carcinoembryonic antigen , metaplasia , adenoma , intestinal polyp , intestinal metaplasia , secretion , cancer
A combined morphologic and histochemical study of metaplastic polyps of the colorectum was undertaken. With increasing size, these lesions showed alterations in architecture and differentiation, increased secretion of carcinoembryonic antigen and a reduced secretion of O‐acylated sialomucin. These functional changes are also observed in colorectal cancers, but not in tubular adenomas showing low‐grade dysplasia. Since there is little clinical evidence for a metaplastic polyp‐carcinoma sequence, it is suggested that the sets of factors which lead to adenoma and metaplastic polyp formation in the colorectum are both required to induce malignant transformation.