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Adenocarcinoma of the proximal colon sites of initial dissemination and patterns of recurrence following surgery alone
Author(s) -
Russell Anthony H.,
Tong Daphne,
Dawson Lynne E.,
Wisbeck William
Publication year - 1984
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19840115)53:2<360::aid-cncr2820530232>3.0.co;2-u
Subject(s) - medicine , laparotomy , surgery , stage (stratigraphy) , adenocarcinoma , abdomen , colorectal cancer , adjuvant therapy , cancer , chemotherapy , paleontology , biology
Seven hundred ninety‐five patients were adenocarcinomas of the proximal colon were reviewed. Two hundred forty‐five patients presented with disseminated disease at the time of diagnosis, and were analyzed to identify mechanisms and sites of disease spread. Five hundred fifty patients underwent radical resection, and were followed for a minimum of 48 months or until time of documented relapse. One hundred eightysix patients (34%) manifested recurrent carcinoma, 64 (34.5%) of whom underwent second laparotomy at the time of initial recurrence. In 139 patients (74.5%), the distribution of clinical recurrence was confined to the abdomen, retroperitoneum, and liver. Prognostic influence of initial stage and tumor grade are analyzed, and possible implications for surgical staging and adjuvant therapy are discussed.