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Failure to demonstrate a chromosome 2 deletion in adenomatous colorectal polyposis patients
Author(s) -
Fineman Robert M.,
Morgan Martha,
Burt Randall W.,
Gardner Eldon J.
Publication year - 1984
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19840115)53:2<317::aid-cncr2820530223>3.0.co;2-c
Subject(s) - familial adenomatous polyposis , chromosome , medicine , colorectal cancer , adenomatous polyposis coli , cytogenetics , gastroenterology , genetics , abnormality , biology , cancer , gene , psychiatry
A group of researchers recently reported a specific chromosome abnormality consisting of a deletion in the long arm (q) of chromosome 2 in patients with adenomatous colorectal polyposis. Using a high resolution chromosome banding technique and a blind study design, the authors karyotyped two patients with Gardner syndrome, two patients with familial polyposis, and four normal controls. No deletion was found in chromosome 2.