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Hodgkin's disease in children. A ten‐year experience in South Africa
Author(s) -
Jacobs Peter,
King Helen S.,
Karabus Cyril,
Hartley Paddy,
Werner Dudley
Publication year - 1984
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19840115)53:2<210::aid-cncr2820530204>3.0.co;2-z
Subject(s) - procarbazine , medicine , vincristine , prednisone , stage (stratigraphy) , complete remission , vinblastine , surgery , radiation therapy , spontaneous remission , chemotherapy , disease , pediatrics , cyclophosphamide , paleontology , alternative medicine , biology , pathology
Twenty‐seven children with Hodgkin's disease were treated with MVOPP (mustine, Velban [vinblastine], Oncovin [vincristine], procarbazine, prednisone) combination chemotherapy. All II children with Stage I or Stage II disease achieved complete remission and no relapses have occurred between 34 and 179 months of continuous follow‐up. Of the 16 children with Stage III or Stage IV disease, two with partial remission and three nonresponding patients died with a median survival of 18 months. The remaining II (68%) achieved complete remission. Of these, 6 (55%) have relapsed with a median remission duration of 36 months; five have been retreated with MVOPP, and one with total nodal irradiation, and all achieved second complete remission. Three of the children have died of Hodgkin's disease, with a median survival of 55 months; one child died of acute myeloblastic leukemia while in remission; and one child remains disease‐free off all therapy at 165 months; the sixth child treated with total nodal irradiation is disease‐free at 166 months. The initial complete remission has been sustained in all II children with Stage I or Stage II Hodgkin's disease, suggesting that combination chemotherapy is an alternative to radiotherapy as the initial form of treatment in this group of individuals.