Premium
Carcinoma of the gallbladder with an anomalous connection between the choledochus and the pancreatic duct. Report of 10 cases and review of the literature in Japan
Author(s) -
Kinoshita Hiroaki,
Nagata Eiichi,
Hirohashi Kazuhiro,
Sakai Katsuji,
Kobayashi Yasutsugu
Publication year - 1984
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(1984)54:4<762::aid-cncr2820540429>3.0.co;2-k
Subject(s) - medicine , gallbladder , gastroenterology , carcinoma , pancreatic duct , metaplasia , gallstones , adenocarcinoma , intestinal metaplasia , bile duct , cholecystitis , pathology , general surgery , dysplasia , pancreatitis , cancer
During the last 8 years, the authors had experience with 10 cases of carcinoma of the gallbladder with an anomalous connection between the choledochus and the pancreatic duct. These cases were studied in reference to age, sex, frequency of gallstones and dilatation of the bile duct, amylase levels in bile, direct cholangiograms, histologic findings, methods of treatment, and prognosis. Histologically, intestinal metaplasia was noticed in cancerous areas and also in noncancerous areas of differentiated adenocarcinomas. These facts suggest that in carcinoma of the gallbladder with this anomaly, reflux and stasis of pancreatic juice in the gallbladder may induce chronic cholecystitis which leads to mucosal metaplasia and, eventually, to differentiated adenocarcinoma.