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A controlled trial of prophylactic granulocyte transfusions during induction chemotherapy for acute nonlymphoblastic leukemia
Author(s) -
GomezVillagran Jose Luis,
Torresgómez Antonio,
GomezGarcia Pedro,
MartinezGuibelalde Francisco,
VelascoJimena Francisco
Publication year - 1984
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(1984)54:4<734::aid-cncr2820540424>3.0.co;2-w
Subject(s) - medicine , chemotherapy , acute leukemia , pneumonia , randomized controlled trial , prophylactic treatment , surgery , granulocyte , incidence (geometry) , induction chemotherapy , leukemia , gastroenterology , physics , optics
Thirty‐five noninfected patients undergoing induction chemotherapy for acute nonlymphoblastic leukemia (ANLL) were randomized to either receive (19 patients) or not receive (16 control patients) prophylactic granulocyte transfusions (PGT) when their granulocyte count fell below 0.5 × 10 9 /I. Both groups received identical anti‐infectious and supportive care except for granulocyte transfusions. The authors found a nonstatistically significant decrease of the infection rate in the prophylactic group. However, the bacteriologically documented infections and septicemia incidence was significantly higher in the control than in the prophylactic group ( P < 0.05). In the control group they observed in 8 of 16 cases life‐threatening infections in contrast with only 1 case in the prophylactic group ( P < 0.01). A significant reduction of deaths due to infectious causes in the prophylactic versus control group were also found ( P < 0.05). The authors did not find an increase of pneumonia or pulmonary infiltrates in the patients belonging to prophylactic in comparison to control group.