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Elevated concentrations of substance p and 5‐HT in plasma in patients with carcinoid tumors
Author(s) -
Emson Piers C.,
Gilbert Richard F. T.,
Martensson Hans,
Nobin Anders
Publication year - 1984
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(1984)54:4<715::aid-cncr2820540420>3.0.co;2-6
Subject(s) - substance p , carcinoid tumors , medicine , circulatory system , gel permeation chromatography , endocrinology , pathology , neuropeptide , receptor , chemistry , organic chemistry , polymer
Ten patients with metastatic carcinoid tumors in the liver showed elevated 5‐hydroxytryptamine and substance P levels in plasma samples taken from hepatic or peripheral veins. Chromatographic characterization of the substance P‐immunoreactivity showed that by gel permeation and high pressure liquid chromatography the substance P‐immunoreactivity was indistinguishable from synthetic undecapeptide substance P. The results suggest that substance P, in addition to the 5‐hydroxyinoles, may serve as a circulatory marker for some forms of carcinoid tumors.