Premium
Synthesis and catabolism of PGE 2 by a nephroblastoma associated with hypercalcemia without bone metastases
Author(s) -
Calò Lorenzo,
Cantaro Salvatore,
Bertazzo Lorenzo,
Vianello Alberto,
Vido Loredana,
Borsatti Arturo
Publication year - 1984
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(1984)54:4<635::aid-cncr2820540408>3.0.co;2-m
Subject(s) - arachidonic acid , catabolism , medicine , phospholipase a2 , prostaglandin e2 , overproduction , endocrinology , enzyme , biochemistry , metabolism , biology
PGE 2 overproduction by a nephroblastoma associated with hypercalcemia was clearly demonstrated in a 2‐month‐old girl. Compared with normal tissue, tumor showed greater phospholipase A 2 and PGE 2 synthetase activities but metabolized PGE 2 at a faster rate. Of the enzymes involved in PGE 2 synthesis, those which transform arachidonic acid into PGE 2 seem to be more active.