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Carcinoembryonic antigen in gastric juice collected during endoscopy. Value in detecting high‐risk patients and gastric cancer
Author(s) -
Nitti D.,
Farini R.,
Grassi F.,
Cardin F.,
Di Mario F.,
Piccoli A.,
Vianello F.,
Farinati F.,
Favretti F.,
Lise M.,
Naccarato Md R.
Publication year - 1983
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19831215)52:12<2334::aid-cncr2820521228>3.0.co;2-7
Subject(s) - medicine , carcinoembryonic antigen , endoscopy , cancer , gastroenterology , value (mathematics) , statistics , mathematics
In order to ascertain the role of gastric carcinoembryonic antigen (CEA) determination in detecting patients with a risk for gastric cancer, 69 subjects were studied; 23 were referred for endoscopy because of dyspepsia but without obvious macroscopic lesions, 27 with duodenal ulcer, 11 with benign gastric ulcer, 8 with gastric cancer. The following results were obtained by subdividing the material according to the histologic interpretation of the results of gastric mucosal biopsies: (1) in the presence of minor histologic abnormalities of the gastric mucosa, CEA in gastric juice was under 100 ng/ml in all but five cases; and (2) in moderate or severe chronic atrophic gastritis (associated or otherwise with intestinal metaplasia or dysplasia), and in gastric cancer, gastric CEA ranged between 224 and 3120 ng/ml in all but two cases. Although not diagnostic for gastric cancer, gastric CEA is a promising test in detecting patients at risk, including those with dysplasia of the gastric mucosa. Cancer 52:2334‐2337, 1983.