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Central nervous system relapse after bone marrow transplantation for acute myeloid leukemia
Author(s) -
To Luen B.,
Chin David K. F.,
Blumbergs Peter C.,
Burrow Donald D.,
Juttner Christopher A.
Publication year - 1983
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19831215)52:12<2236::aid-cncr2820521212>3.0.co;2-n
Subject(s) - medicine , chemotherapy , spinal cord , myeloid leukemia , central nervous system , bone marrow , autopsy , transplantation , pathology , lumbosacral joint , surgery , psychiatry
Abstract Central nervous system (CNS) relapse with meningeal leukaemia occurred 6 months after allogeneic bone marrow transplantation (BMT) for acute myeloid leukaemia, without systemic relapse. Despite intrathecal chemotherapy a severe progressive proprioceptive impairment of the lower limbs developed. Autopsy revealed selective ascending tract degeneration of the gracile fasciculi of the posterior columns of the spinal cord and residual endoneurial deposits were found in lumbosacral dorsal nerve roots and ganglia. While CNS relapse may occur in acute leukaemia after chemotherapy, it has rarely been reported following BMT. Cancer 52:2236‐2239, 1983.