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Anaplastic carcinoma of the thyroid with osteoclast‐like giant cells
Author(s) -
Esmaili Jaleh H.,
Hafez Gholam Reza,
Warner Thomas F. C. S.
Publication year - 1983
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19831201)52:11<2122::aid-cncr2820521125>3.0.co;2-3
Subject(s) - giant cell , pathology , neoplasm , multinucleate , medicine , osteoclast , thyroid , carcinoma , anaplastic carcinoma , receptor
An unusual malignant thyroid neoplasm with a morphologic resemblance to giant cell tumor of the bone is reported in a patient who presented with a rapidly growing thyroid mass and a history of pre‐existing goiter. The light and electron microscopic studies disclosed areas of differentiated follicular carcinoma with gradual transition to undifferentiated carcinoma. Pleomorphic spindle‐shaped cells and giant cells were accompanied by numerous osteoclast‐like multinucleated giant cells. Desmosomes and interdigitating cell surfaces were apparent in the differentiated as well as undifferentiated areas on electron microscopy. These findings support an epithelial rather than a mesenchymal origin for this neoplasm. Cancer 52:2122‐2128, 1983.