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Malignant histiocytosis
Author(s) -
Esseltine Dixie W.,
De Leeuw NANNIE K. M.,
Berry Gerry R.
Publication year - 1983
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19831115)52:10<1904::aid-cncr2820521022>3.0.co;2-k
Subject(s) - medicine , chemotherapy , malignant histiocytosis , bone marrow , disease , malignant disease , histiocytosis x , organ dysfunction , histiocytosis , radiology , oncology , surgery , cancer , pathology , sepsis , histiocyte
The clinical features, therapy, and hospital course of ten consecutive patients with malignant histiocytosis (MH) are presented. The value of bone marrow aspiration for the diagnosis is discussed. The patient's performance status as described in this report by the organ dysfunction score may predict survival and response to chemotherapy. The literature on chemotherapy in this disease is reviewed. Combination chemotherapy may be the best approach to treatment, but there is little experience with single agents. There is a great need for better characterization of the malignant cell in this disorder.