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Localized amyloidosis in basal cell carcinoma. A pathologic study
Author(s) -
Looi Lai Meng
Publication year - 1983
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19831115)52:10<1833::aid-cncr2820521012>3.0.co;2-o
Subject(s) - pathology , amyloid (mycology) , medicine , stromal cell , basal cell carcinoma , stroma , amyloidosis , neoplasm , congo red , basal (medicine) , carcinoma , basal cell , immunohistochemistry , chemistry , organic chemistry , adsorption , insulin
Congo‐red screening demonstrated intratumor deposits of amyloid in 35 of 53 unselected cases of basal cell carcinoma. Male subjects had a higher amyloid positivity rate than female subjects. The amyloid deposits were permanganate‐resistant and located in the stroma between clumps of tumor cells, as well as abutting the advancing front of the neoplasm. Solar elastosis was often observed in the overlying and adjacent subepidermis. The relationship between amyloid positivity and the different histological subtypes of basal cell carcinoma, tumor ulceration, and density of the lymphoplasmacytic stromal infiltrate were also studied. The possibility that amyloid originates from the tumor cells and is a result of tumor apoptosis (degeneration) is discussed.