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S‐100 protein in tumors of cartilage and bone: An immunohistochemical study
Author(s) -
Nakamura Yasuhiro,
Becker Laurence E.,
Marks Alexander
Publication year - 1983
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19831115)52:10<1820::aid-cncr2820521010>3.0.co;2-3
Subject(s) - chondroblastoma , immunohistochemistry , chondrosarcoma , osteoblastoma , osteosarcoma , pathology , medicine , chondroma , cartilage , mesenchymal chondrosarcoma , chondrocyte , mesenchymal stem cell , anatomy
Using the peroxidase‐antiperoxidase (PAP) immunohistochemical method, S‐100 protein was found in well‐differentiated chondrocytes of chondroma, chondroblastoma, mesenchymal chondrosarcoma, and osteosarcoma. It was not detected in osteoma, osteoblastoma, giant cell tumor, and Ewing's tumor. The presence of S‐100 protein in tumorous chondrocytes and chondroblasts suggests that this protein may be a marker of chondrocyte origin and should not be considered a specific marker for nerve tissue.