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Dedifferentiation of a transplantable papillary thyroid carcinoma over a 15‐year period
Author(s) -
Orvoine Robert H.,
Cantin Marc,
Garzon Simon,
Billick Robin C.,
Stephens Heather,
Strykowski Henri
Publication year - 1983
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19831101)52:9<1720::aid-cncr2820520928>3.0.co;2-k
Subject(s) - medicine , basement membrane , pathology , thyroid , carcinoma , golgi apparatus , endocrinology , anatomy , biology , cell , genetics
Fischer 344 rats on a prolonged low‐iodine diet developed thyroid nodules which were transplanted subcutaneously into 33 thyroidectomized rats. One graft took and gave a papillary carcinoma. Serially transplanted syngeneically at 3‐ to 4‐month intervals, it became autonomous in third generation hosts. With electron microscopy examination it was microfollicular in year 8 and anaplastic, with totally unpolarized epithelial cells, in year 15. Basement membrane present in year 1 was no longer visible in specimens of years 8 and 15. Tight and gap junctions still present in year 8 were absent in year 15, although a few desmosomes persisted. From years 8 to 15, free ribosomes and microfilaments became more frequent, whereas the number of mitochondria and the development of the Golgi complex declined.