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Late relapse from complete remission in nodular and diffuse histiocytic lymphoma
Author(s) -
Mead Graham M.,
MacKintosh F. Roy,
Burke Jerome S.,
Rosenberg Saul A.
Publication year - 1983
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19831015)52:8<1356::aid-cncr2820520803>3.0.co;2-m
Subject(s) - medicine , histiocyte , lymphoma , complete remission , radiation therapy , pathology , chemotherapy
Twelve patients with unfavorable prognosis lymphomas (diffuse histiocytic lymphoma, 11; nodular histiocytic lymphoma, 1) treated predominantly with radiation therapy, are described in whom relapse of disease occurred late (>2.5 years, 2.8–26 years; median, 6.25 years) after achieving a complete remission. Although relapse probably represented regrowth of clinically quiescent tumor, it is also possible that these were second malignancies, perhaps occurring in a predisposed host. Continued long‐term analysis of clinical trials is important to document this uncommon occurrence.