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Arterial prostacyclin generation is decreased in patients with malignant bone tumors
Author(s) -
Mehta Paulette,
Springfield Dempsey,
Ostrowski Nancy
Publication year - 1983
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19831001)52:7<1297::aid-cncr2820520727>3.0.co;2-l
Subject(s) - medicine , prostacyclin , blood vessel , pathology
Arterial production of PGI 2 was measured in patients with malignant bone tumors and compared to that in arteries from subjects with benign bone tumors and others without tumor. Arteries from all study subjects exhibited spontaneous and arachidonate‐induced PGI 2 release. Arterial production of PGI 2 as measured by 6–keto‐PGF 1 a was in the normal range in patients with benign tumors. In contrast, arteries from patients with malignant tumors had lower PGI 2 release. Deficient arterial PGI 2 production in patients with malignant tumor was present both at rest and upon stimulation of blood vessels with arachidonate. Decreased PGI 2 generation could relate to tumor attachment to the endothelium, penetration of the vessel walls and subsequent metastasis.