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A histopathologic study of benign and malignant lymphoepithelial lesions of the parotid gland
Author(s) -
Nagao Koichi,
Matsuzaki Osamu,
Saiga Hajime,
Akikusa Bunshiro,
Sugano Isamu,
Shigematsu Hidekazu,
Kaneko Toshio,
Katoh Takayuki,
Kitamura Takeshi,
Asano Yoshinori,
Okamoto Makoto
Publication year - 1983
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19830915)52:6<1044::aid-cncr2820520620>3.0.co;2-r
Subject(s) - pathology , medicine , stromal cell , parotid gland , carcinoma , lesion
Twenty‐three cases of benign and malignant lymphoepithelial lesions without Sjögren's syndrome were examined: 21 were classical benign lymphoepithelial lesions, and were mostly found in males older than 50 years of age. The other two cases were identified as undifferentiated carcinoma arising from benign lymphoepithelial lesion (8.7%; 2/23). Histologically, this carcinoma is characterized by the formation of cell nests of variable size and by marked lymphoplasmacytic infiltrations into the stromal tissue. In immunofluorescence, an increase of plasma cells containing IgA and IgG was noted in the marginal areas of carcinoma cell clusters. Electron microscopy disclosed that the carcinoma was composed of poorly differentiated cells with occasional squamous differentiation. No dysplastic characteristics were found in the infiltrating lymphocytic components. These two cases of carcinoma were found in middle‐aged females.