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Computerized histopathologic assessment of malignant potential. II. As practical method for predicting survival following enucleation for uveal melanoma
Author(s) -
Gamel John W.,
McLean Ian W.
Publication year - 1983
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19830915)52:6<1032::aid-cncr2820520618>3.0.co;2-b
Subject(s) - enucleation , medicine , melanoma , melanoma diagnosis , pathology , eye enucleation , dermatology , surgery , cancer research
To assess the malignant potential of uveal melanomas from standard histopathologic material, a single microslide from each of 100 cases underwent computer‐assisted measurement of nucleolar cross‐sectional area. The standard deviation of 200 measurements per slide correlated well with survival of patients following enucleation for their ocular tumor. Furthermore, a statistical model calculated from these measurements effectively predicted survival for 50 additional cases. Additional investigation demonstrated the following features of this method: (1) a high level of reproducibility; (2) acceptable constancy among different levels of the same tumor; (3) a practical expenditure of resources (assessment of each case required less than 40 minutes of a technician's time and an apparatus costing approximately $20,000). This method—computerized histopathologic assessment of malignant potential (CHAMP)—thus provides the pathologist with a practical method for extracting prognostic information from standard H & E‐stained microslides of uveal melanomas. Previous studies by other researchers suggests that a similar method might be effective in assessing the malignant potential of more common neoplasms.