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The association of Fanconi's anemia and squamous cell carcinoma
Author(s) -
Reed Kendall,
Ravikumar Thanjavur S.,
Gifford ROBERT R. M.,
Grage Theodor B.
Publication year - 1983
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19830901)52:5<926::aid-cncr2820520530>3.0.co;2-t
Subject(s) - fanconi anemia , medicine , pancytopenia , anemia , basal cell , leukemia , pathology , bone marrow , biology , genetics , gene , dna repair
Fanconi's anemia is a rare autosomal recessive disorder which manifests itself in early childhood, presenting as pancytopenia, pigmentation changes, skeletal deformities, small statures and chromosomal aberrations. Most patients ultimately die from sepsis as a result of their hematologic abnormalities, however, some patients live long enough to develop malignancies such as leukemia, hepatocellular carcinomas and squamous cell carcinoma. The association of Fanconi's anemia and squamous cell carcinoma is examined with a report of a patient with Fanconi's anemia and squamous cell carcinoma of the pyriform sinus and hypopharynx.