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Intensive combination chemotherapy for cancer of the oral cavity
Author(s) -
Khan. N.,
Srivastava P. K.,
Khanna S.,
Das S. N.
Publication year - 1983
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19830901)52:5<790::aid-cncr2820520506>3.0.co;2-v
Subject(s) - medicine , cyclophosphamide , bleomycin , methotrexate , chemotherapy , cancer , toxicity , cancer chemotherapy , oral administration , combination chemotherapy , oncology
Abstract Thirty advanced cases of cancer of the oral cavity were treated by intensive combination chemotherapy using bleomycin, methotrexate, 5‐fluorouracil, cyclophosphamide, and Oncovin administered over a period of 48 hours. Bleomycin was given as a continuous infusion and Oncovin was administered six hours prior to the administration of other drugs. A clinical response was obtained in 73.3% of the cases, a complete response in 33.3%, and a partial response in 40%. The toxicity was within acceptable limits.