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Control of pleural effusions in patients with breast cancer a randomized trial
Author(s) -
Fentiman Ian S.,
Rubens Robert D.,
Hayward John L.
Publication year - 1983
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19830815)52:4<737::aid-cncr2820520428>3.0.co;2-8
Subject(s) - medicine , randomized controlled trial , breast cancer , pleural effusion , talc , surgery , effusion , pleurodesis , complication , malignant pleural effusion , cancer , materials science , composite material
In a controlled randomized trial, 46 patients with pleural effusions secondary to breast cancer were treated at first diagnosis with either intracavitary mustine or talc, to determine which agent produced the more effective pleurodesis. Of the 37 evaluable patients, control of the effusion was achieved in 9/17 (56%) of those treated with mustine and 18/20 (90%) of the talc group ( P > 0.025). This suggests that early treatment with intracavitary talc can effectively palliate this complication of breast cancer.