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Histochemical characterization of different types of intestinal metaplasia in gastric mucosa
Author(s) -
Segura D. I.,
Montero Claudio
Publication year - 1983
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19830801)52:3<498::aid-cncr2820520320>3.0.co;2-8
Subject(s) - intestinal metaplasia , medicine , gastroenterology , pathology , carcinoma , metaplasia , small intestine , large intestine , pepsin , gastric carcinoma , stomach , cancer , biology , enzyme , biochemistry
The histochemical patterns of mucosubstances in 1.010 intestinal metaplasia (IM) foci in stomachs removed during surgery for benign ulcer and carcinoma has been studied. Two kinds of IM were characterized: the complete and the incomplete types, with the first one subdivided in Small intestine Type I, Small intestine Type II, and Colonic type, based on their similarity of mucosubstances, with those found in normal small intestine and colon, and the second one divided in two groups, depending on the presence or absence of sulfomucins. The incomplete type with sulfomucins was significantly more frequent in patients with carcinoma than in benign ulcer cases ( P < 0.001) as well as, in stomachs bearing intestinal type of carcinoma than in stomachs with diffuse type of carcinoma ( P < 0.005). The significance of the different types of IM, in relation to the gastric pathologic findings is discussed.