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Immune restoration and/or augmentation of local graft versus host reaction by traditional chinese medicinal herbs
Author(s) -
Sun Van,
Hersh Evan M.,
Talpaz Moshe,
Lee SiuLeung,
Wong Wendy,
Loo Ti Li,
Mavligit Giora M.
Publication year - 2006
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19830701)52:1<70::aid-cncr2820520114>3.0.co;2-s
Subject(s) - medicine , medicinal herbs , chinese herbs , host (biology) , immune system , traditional medicine , local reaction , immune reaction , immunology , traditional chinese medicine , biology , pathology , alternative medicine , ecology
The in vitro restorative effect of aqueous extracts from two traditional Chinese medicinal herbs were studied in 19 cancer patients and in 15 normal healthy donors. Using the local graft versus host (GVH) reaction as a test assay for T‐cell function, the extract from astragalus membranaceus (10 μg/ml) induced a restored reaction in nine of ten patients with an increase in local GVH reaction from 18.2 ± 15.8 mm 3 to 112.9 ± 94.2 mm 3 ( P < 0.01). The extract from ligustrum lucidum , likewise effected an immune restoration in nine of 13 cancer patients with an increase in local GVH reaction from 32.3 ± 36.1 mm 3 to 118 ± 104.9 mm 3 ( P < 0.01). This degree of immune restoration appears to be complete as it equals the local GVH reaction observed among untreated mononuclear cells from normal healthy donors (82.8 ± 41.1 mm 3 , P > 0.1). These results suggest that both extracts of the traditional Chinese medicinal herbs contain potent immune stimulants which may provide the rational basis for their therapeutic use as biological response modifiers. Cancer 52:70‐73, 1983.