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Neuroblastoma associated with beckwith‐wiedemann syndrome
Author(s) -
Emery Linda G.,
Shields Mary,
Shah Narayan R.,
Garbes Archimedes
Publication year - 2006
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19830701)52:1<176::aid-cncr2820520132>3.0.co;2-v
Subject(s) - beckwith–wiedemann syndrome , medicine , neuroblastoma , malignancy , neural crest , ganglioneuroblastoma , incidence (geometry) , pediatrics , pathology , ganglioneuroma , embryo , biochemistry , gene expression , chemistry , genetics , physics , biology , microbiology and biotechnology , optics , dna methylation , gene , cell culture
This report describes an infant with Beckwith‐Wiedemann Syndrome (BWS) found to have a thoracic neuroblastoma. Infants with BWS are known to have an increased incidence of tumors (10%). We believe this to be the first report of a malignant neural crest tumor in a child with BWS and also the first case occurring in familial BWS. Usually the malignancies associated with the BWS are intra‐abdominal; however, this malignancy was located in the chest. It is important to detect malignancy in early stages. Therefore, recommendations for screening children with BWS are discussed. Cancer 52:176‐179, 1983.