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Epidermal growth factor‐urogastrone receptors in normal human liver and primary hepatoma
Author(s) -
Costrini Nicholas V.,
Beck Rosalie
Publication year - 1983
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19830615)51:12<2191::aid-cncr2820511207>3.0.co;2-q
Subject(s) - medicine , receptor , primary (astronomy) , epidermal growth factor , endocrinology , physics , astronomy
Epidermal growth factor‐urogastrone (EGF‐URO) receptors have been demonstrated in rodent liver and modulation of ligand binding during transformation has been shown in a variety of study systems. A patient presented with a resectable primary hepatoma arising in a histologically normal liver. We carried out ligand binding studies using 125 I‐EGF and homogenates or plasma membrane preparations of normal and hepatoma tissues. EGF‐URO receptors were demonstrated in normal human liver; half‐maximal binding occurred at 2.5 × 10 −9 M 125 I‐EGF. Binding decreased in association with hepatoma formation. These results provide initial evidence that EGF‐URO receptors exist in human liver and that ligand binding changes accompany hepatoma formation in man.