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Family history, oral contraceptive usage, and breast cancer
Author(s) -
Black Maurice M.,
Barclay Thomas H. C.,
Polednak Anthony,
Kwon C. Stephan,
Leis Henry P.,
Pilnik Samuel
Publication year - 1983
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19830601)51:11<2147::aid-cncr2820511133>3.0.co;2-x
Subject(s) - medicine , family history , breast cancer , family medicine , gynecology , family planning , cancer , obstetrics , population , research methodology , environmental health
When breast cancer patients were grouped according to their family history of breast cancer striking differences were found in age distribution. Thus, the proportion of cases <45 years of age was grandmother > aunt > mother > FH‐negative > sister. A similar FH‐related sequence was observed in regard to current OC usage among breast cancer patients <45 years of age. It also appeared that current oral contraceptive (OC) usage increased the risk of invasive breast cancer among grandmother‐ or aunt‐positive women while decreasing the risk among FH‐negative women. There are important practical and conceptual reasons for further studies of the influence of interactions between age, OC usage and family history on the stepwise development of breast cancer.