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Interrelationships of histopathology and other clinical variables in patients with germ cell tumors of the testis
Author(s) -
Bosl George J.,
Geller Nancy,
Cirrincione C.,
Hajdu Steven I.,
Whitmore Willet,
Nisselbaum Jerome,
Vugrin Davor,
Golbey Robert B.
Publication year - 1983
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19830601)51:11<2121::aid-cncr2820511128>3.0.co;2-2
Subject(s) - choriocarcinoma , medicine , human chorionic gonadotropin , histopathology , germ cell tumors , carcinoembryonic antigen , metastasis , germ cell , stage (stratigraphy) , pathology , cell , seminoma , teratoma , oncology , chemotherapy , biology , cancer , hormone , paleontology , biochemistry , genetics , gene
Possible relationships between histopathologic cell type and several clinical variables were examined in 253 patients with Stage III nonseminomatous germ cell tumors of the testis. No statistically significant associations were found between cell type and either the side of primary tumor or cryptorchidism. The presence of elements of choriocarcinoma was associated with the presence of retroperitoneal tumor ( P < 0.03) but no other association between cell type and site of metastasis was encountered. Elevated serum levels of human chorionic gonadotropin were found in patients with elements of choriocarcinoma but serum levels of alphafetoprotein, lactate dehydrogenase and carcinoembryonic antigen were not correlated with a specific cell type. No statistically significant association was found between cell type and either complete response to combined modality therapy or survival. These results would indicate that cell type is probably not an important prognostic variable in patients with Stage III nonseminomatous tumors of the testis.