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Steroid receptors in breast angiosarcoma
Author(s) -
Brentani M. M.,
Pacheco M. M.,
Oshima C. T. F.,
Nagai M. A.,
Lemos L. B.,
Góes J. C. S.
Publication year - 1983
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19830601)51:11<2105::aid-cncr2820511125>3.0.co;2-1
Subject(s) - receptor , estrogen receptor , endocrinology , estrogen , glucocorticoid receptor , nuclear receptor , medicine , pelp 1 , progesterone receptor , cytosol , steroid , estrogen related receptor gamma , glucocorticoid , breast cancer , chemistry , hormone , cancer , biochemistry , enzyme , transcription factor , gene
The presence of receptors for estrogen, glucocorticoid and progesterone was determined in the cytosol of two breast angiosarcomas. Estrogen and glucocorticoid receptors were present in both of them. Progesterone receptors were present in one of the two tumors assayed. Occupied nuclear estrogen receptors have been found in the nuclear extracts of both tumors. Unoccupied nuclear receptors were found only in the progesterone‐positive tumor. Density gradient analysis suggested that glucocorticoid and estrogen bindings were located predominantly in the 6S and 7 to 8S regions, whereas receptor for progesterone sedimented at 4S.