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Effects of in vitro hyperthermia on murine and human lymphocytes
Author(s) -
Izumi Akio,
Koga Shigemasa,
Maeta Michio
Publication year - 1983
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19830601)51:11<2061::aid-cncr2820511118>3.0.co;2-2
Subject(s) - hyperthermia , in vitro , immune system , cytotoxic t cell , medicine , immunology , lymphocyte , andrology , biology , biochemistry
The effect of in vitro hyperthermia on the immune response of murine and human lymphocytes was investigated. Viability, blastogenesis and cytotoxic activity of murine lymphocytes were reduced at 39 and 42°C hyperthermia. In human lymphocytes, rosette formation inhibition depended on heating‐time and temperature. PHA‐induced lymphocyte blastogenesis was markedly inhibited at 42°C, irrespective of the duration of exposure and of the origin of the cells, although it was enhanced in some patients at 39°C. Therefore, the possibility of hyperthermia‐induced inhibition of the host immune response must be considered in clinical trials of total‐body hyperthermia for cancer.