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Cis‐platin based combination chemotherapy for advanced ovarian cancer. High overall response rate with curative potential only in women with small tumor burdens
Author(s) -
Vogl Steven E.,
Pagano Marcello,
Kaplan Barry H.,
Greenwald Edward,
Arseneau James,
Bennett Boyce
Publication year - 1983
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19830601)51:11<2024::aid-cncr2820511111>3.0.co;2-i
Subject(s) - medicine , chemotherapy , cyclophosphamide , toxicity , melphalan , ovarian cancer , vomiting , cancer , surgery , oncology , doxorubicin , progressive disease , nausea , peripheral neuropathy , survival rate , gastroenterology , endocrinology , diabetes mellitus
Abstract Thirty‐eight women with advanced ovarian cancer were given monthly cycles of intravenous cyclophosphamide, Adriamycin (doxorubicin) and cis‐platin, and oral hexamethylmelamine. Of 26 with tumor which would be evaluated for response, 42% had complete remission and 50% partial remission. Median time to disease progression from entry for all 38 patients was 13 months, and median survival 23.5 months. The bulk of tumor at the time chemotherapy was begun was the only significant prognostic factor for time to disease progression and survival. Of the seven women surviving free of disease a median of three years later, five had no mass > 2 centimeters in diameter at entry. Toxicity was predominantly myelosuppression and vomiting, with mild peripheral neuropathy in 27% and no significant renal or cardiac toxicity. The response rate of 92% is much higher than that previously reported with melphalan, and the survival considerably longer. The toxicity is acceptable, given the substantial improvement in results.