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High relative frequency of thyroid papillary carcinoma in northern portugal
Author(s) -
Sambade Maria C.,
Goncalves Vicente S.,
Dias Manuel,
SobrinhoSimòes Manuel A.
Publication year - 1983
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19830501)51:9<1754::aid-cncr2820510932>3.0.co;2-f
Subject(s) - medicine , goiter , thyroid , papillary carcinoma , carcinoma , follicular phase , malignancy , thyroid carcinoma , follicular carcinoma , iodine , thyroiditis , physiology , endocrinology , pathology , materials science , metallurgy
Two hundred and twelve papillary and 40 follicular carcinomas were found in 3002 thyroid glands examined from 1931 to 1975 in four Laboratories of Pathology that fairly cover northern Portugal. There was a striking preponderance of women both in papillary (female:male = 6.9:1) and follicular carcinoma (5.7:1). Sex‐specific frequency of malignancy was significantly greater in men (13.3%) than in women (8.8%). The overall papillary/follicular ratio was 5.3:1 and did not significantly change throughout the study period. Papillary/follicular ratio was not significantly greater in litoral (5.5:1) than in regions with a low iodine intake and a relatively high prevalence of goiter (3.5:1). It is advanced that this high relative frequency of papillary carcinoma in northern Portugal, even in goiter areas, may reflect the existence of a racial factor since there is not enough evidence to support the influence of dietary iodine, previous irradiation and concurrent thyroiditis.