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Primary anaplastic small cell (oat cell) carcinoma of the larynx. Review of the literature and report of 18 cases
Author(s) -
Gnepp Douglas R.,
Ferlito Alfio,
Hyams Vincent
Publication year - 1983
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19830501)51:9<1731::aid-cncr2820510929>3.0.co;2-6
Subject(s) - medicine , larynx , anaplastic carcinoma , histogenesis , oat cell carcinoma , small cell carcinoma , carcinoma , pathology , large cell , radiation therapy , otorhinolaryngology , neoplasm , laryngeal neoplasm , chemotherapy , cancer , respiratory disease , lung , surgery , adenocarcinoma , immunohistochemistry
Anaplastic small cell (oat cell) carcinoma is a neoplasm commonly arising in the lungs. However, it may also occur, though rarely, in the larynx. A series of 43 cases is presented (ten cases from the Armed Forces Institute of Pathology, eight from the Department of Otolaryngology of the Padua University, and 25 from the literature). The tumor often presents in the sixth and seventh decades of life and appears to be highly aggressive, and metastases develop early. The most common presenting symptom is hoarseness. As in pulmonary small cell carcinoma, prognosis is poor and does not seem to depend upon therapeutic modalities, tumor location or the extent of initial local disease. The tumor seems to derive from the Kulchitsky cell present not only in the bronchial mucosa but also in the laryngeal lining. Like pulmonary anaplastic small cell carcinoma, small cell carcinoma of the larynx should be treated with systemic chemotherapy and radiotherapy. The association of small cell carcinoma with squamous carcinoma of the larynx is also reported and problems connected with the histogenesis of this mixed tumor are discussed.