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An immunohistochemical study of hepatoblastoma producing human chorionic gonadotropin
Author(s) -
Morinaga Shojiroh,
Yamaguchi Masato,
Watanabe Itaru,
Kasai Morio,
Ojima Motoko,
Sasano Nobuaki
Publication year - 1983
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19830501)51:9<1647::aid-cncr2820510916>3.0.co;2-0
Subject(s) - hepatoblastoma , human chorionic gonadotropin , giant cell , alpha fetoprotein , immunohistochemistry , pathology , multinucleate , medicine , gonadotropin , radioimmunoassay , endocrinology , biology , hormone , hepatocellular carcinoma
High tissue concentrations of human chorionic gonadotropin (hCG) and alpha‐fetoprotein (AFP) were revealed by radioimmunoassay in a hepatic tumor which was surgically removed from a two‐year, eight‐month‐old boy manifesting sexual precocity. Histologically the tumor showed an embryonal type hepatoblastoma admixed with multinucleated tumor giant cells. The localization of native hCG and hCG‐beta subunit was immunohistochemically demonstrated in some of the above giant cells, while that of alpha‐fetoprotein was diffusely in the tumor cells of hepatoblastoma of embryonal type. Ultrastructural features of the giant cells were also presented.